This is some information I've gathered up on this particular form of vitamin K2. My chiropractor recently told me about this when I told him I was diagnosed with osteopenia (an early symptom of osteoporosis) He recommended 15mg a day... but I think I will do the 45 mg a day for 3 months as a start and then reduce. I never have approved of all those calcium pills for osteoporosis, as they increase the risk for a lot of other diseases and are rough on the cardio-vascular system. For now, I've decided that while I do this protocol I will take some bone building supplements with calcium/magnesium at a greatly reduced rate along with herbal Silica, but only a couple times a week.. thats right, it will come out to about two full doses of a calcium/magnesium supplement a week. I will also take boron via Borax, in solution, daily with my vitamin D3 of 10,000IU a day… and decreasing to 5,000 IU after a couple of weeks.
After you read these studies you may be convinced that either a low dosage or a higher dosage of 45mg a day is right for you.
https://pubmed.ncbi.nlm.nih.gov/10750566/
https://asbmr.onlinelibrary.wiley.com/doi/full/10.1359/jbmr.2000.15.3.515
For cytopenia/anemia https://www.researchgate.net/publication/11550878_Menatetrenone_a_vitamin_K-2_analog_ameliorates_cytopenia_in_patients_with_refractory_anemia_of_myelodysplastic_syndrome
https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/j.1447-0756.2006.00386.x
For arthritis: https://pubmed.ncbi.nlm.nih.gov/17681015/
https://www.holistichealthnlife.com/mk-4-vs-mk-7-vitamin-k2-supplement-form/
https://www.naturalmedicinejournal.com/journal/2015-10/choosing-right-vitamin-k2-menaquinone-4-vs-menaquinone-7 Vitamin K2 occurs in nature in several forms; each form is designated by the length of the side chain (the number of isoprenoid units) of this fat-soluble molecule. Different forms of vitamin K2 are found in varying amounts in foods of disparate origins. MK-4, a relatively short-chain menaquinone, is found in foods of animal origin, such as butter and egg yolks. Longer-chain menaquinones (MK-5 to MK-10) are found in variable amounts in fermented foods, such as cheese. 5 MK-7 is the predominant form of vitamin K2 in the Japanese fermented soy food natto, and it is of commercial and clinical interest since it is readily available for supplementation.
Synthetic MK-4 supplements were the first to market, and the early research on vitamin K2 starting in the mid-1990s used this form, typically in a dose of 15 mg 3 times per day or 45 mg (45,000 µg) daily. While this dose is very high—and seemingly arbitrary—vitamin K2 is virtually nontoxic, so this became the standard dose in research and clinical practice. One recent study used MK-4 in lower doses, such as 600 µg daily.6 Further studies are required to confirm whether MK-4 is effective in these lower, more dietarily accessible doses.
K for the arteries: https://www.inspire.com/groups/national-osteoporosis-foundation/discussion/k2-mk4-know-which-k2-is-the-best/ ...
K2: Your Arteries’ Best Friend?
Animal studies have shown that K2, but not K1, can inhibit the calcification of arterial plaque. As a recent review notes: “Calcification of the vessel walls is one of the features of atherosclerosis and is by itself considered to be a risk factor for plaque rupture.”38 And plaque rupture in a heart artery is often the final trigger for a (possibly fatal) myocardial infarction (heart attack). A 1996 study found that high-dose K2 inhibited the increase in aortic or kidney calcium induced by megadose synthetic vitamin D2. The authors noted that “a pharmacological dose of vitamin K2 might have a usefulness for the prevention and treatment of arteriosclerosis with calcification.”39 A 1999 study found that high-dose K2 could inhibit the increase in aortic calcium in rats made arteriosclerotic by high-dose D2 and an atherogenic diet.40
A 1997 rabbit study found that high dose K2 “prevents both the progression of atherosclerosis and the coagulative tendency by reducing the total-cholesterol, lipid peroxidation and factor X activity in plasma, and the ester cholesterol deposition in the aorta of hypercholersterolemic rabbits.”41 In 2003 Spronk and colleagues reported “that MK-4 [K2] and not K1 inhibits warfarin-induced arterial calcification.”42
Most importantly, a study published in 2001 examined more than 4,000 humans followed from 1990 to 1996. Subjects were examined for their dietary K2 intake. Those with a “high” K2 intake (greater than 33 mcg per day) had only 43 percent of the risk of suffering a heart attack compared to the low K2 group (less than 22 mcg per day). The risk of dying from a heart attack was only 37 percent as high in the high-K2 group compared to the low-K2 group. “The dietary intake of vitamin K1 showed no consistent relation with cardiac events or aortic atherosclerosis.”
Vitamin K2-mk 7 is very good for you but is not the same as K-4 ... Im still going to take this at 100mcg a day.
Goog buy https://www.vitacost.com/vitacost-vitamin-k2-mk-7-with-nattokinase-100-mcg-200-softgels
This is where Im getting my Vitamin K2 Menaquinone-4. Please avoid using Amazon if you can but if you go to Amazon and read the comments from people who have used this product you will learn a lot.
Purchase here.. it's just about the best price available.
Relentless Improvement K2-mk4-menatetreone
The calcium supplement I've selected is produced by Garden of Life, called Living Calcium Advanced. One dose is 6 tablets. I intend to take 2 tablets a day. If you choose to order from Iherb use my discount code of BAR967. If you order over $20 worth I think it may give you a discount. https://www.iherb.com/pr/Garden-of-Life-Living-Calcium-Advanced-120-Vegetarian-Caplets/7073
i ordered the k2 from Relentless ....... each capsule is 15 mg ......... i don't want to be dividing the capsules, so will take one a day (after meal ?) .
Being i am 73 and have not had knee issues till recently ( almost certainly osteoporosis ) ....
so lets see what happens. I already take mag, and boron.....and 5000 vit d
but my k2 was only 100 mcg . thanks for the info
I have issues which i believe are from age related (73 yrs old) osteoporosis . Was ok till recently when pain in my knees started. I had only been taking vit d without vit k , but recently bought Vit K2 .
Reading your guidelines shocked me . My vit k2 (Now brand) is 100 mcg !
15 MG would equate to 15000 mcg ! Am i missing something here ?
I take 5000 vit d daily ( also magnesium and boron ) .
Seems like 45000 k2 daily is excessive ?
posting this before reading some of the links you posted